Propentofylline For Alzheimer's Disease
Propentofylline is a relatively new drug that markedly slows the progression of alzheimer's disease
for up to 56 weeks . The drug increases Mini Mental State Exam scores in
patients noticeably within 3 months and the effects last for up to one year
[167-168]. The drug also substantially reduces home care and caregiving costs
Propentofylline is usually taken in doses of 300
milligrams, three times daily, one hour before meals. Meals seem to interfere
with the absorption of the drug . The drug is well tolerated and has no
severe side effects.
How does the drug work?
Propentofylline is an adenosine A2 receptor agonist and protects brain cells
from injury . Propentofylline decreases the toxic effects of amyloid beta
protein . The drug also increases the synthesis of nerve growth factor
. Propentofylline is a promising new drug for the treatment of alzheimer's
disease with different modes of action than cholinesterase inhibitors.