Trazodone For Alzheimer's Disease
Trazodone was originally developed in Italy to treat depression. However, the drug has been found useful
to manage agitation in demented patients. One 10-week study gave 13 alzheimer
patients 25 milligrams of trazodone,three times daily. Patients were less
irritable and anxious . Another study compared trazodone,50 to 250
milligrams daily with haloperidol, 1 to 5 milligrams daily. Trazodone and
haloperidol both work equally at controlling agitation; however, trazodone seems
to work best on repetitive or verbal aggressive behavior, whereas haloperidol
seems to work best on excess motor activity .
Trazodone is not free of side effects. Trazodone may occassionally cause
ventricular arrhythmia in patients with preexisting cardiac problems.
Trazodone's most frequent side effects are drowsiness, headache,
gastrointestinal upset, and postural hypotension . A rare but serious side
effect is priapism in males, which may need urologic intervention.