Propentofylline For Alzheimer's Disease
Propentofylline is a relatively new drug that markedly slows the progression of alzheimer's disease
for up to 56 weeks [166]. The drug increases Mini Mental State Exam scores in
patients noticeably within 3 months and the effects last for up to one year
[167-168]. The drug also substantially reduces home care and caregiving costs
[169].
Propentofylline is usually taken in doses of 300
milligrams, three times daily, one hour before meals. Meals seem to interfere
with the absorption of the drug [170]. The drug is well tolerated and has no
severe side effects.
How does the drug work?
Propentofylline is an adenosine A2 receptor agonist and protects brain cells
from injury [171]. Propentofylline decreases the toxic effects of amyloid beta
protein [172]. The drug also increases the synthesis of nerve growth factor
[173]. Propentofylline is a promising new drug for the treatment of alzheimer's
disease with different modes of action than cholinesterase inhibitors.